Enclomiphene

Estrogen receptor modulation can reduce estrogenic feedback at the hypothalamic-pituitary level, increasing gonadotropin signaling and endogenous testicular testosterone production. This differs from supplying exogenous testosterone, which can suppress LH, FSH and intratesticular support for spermatogenesis. The distinction depends on an endocrine system capable of responding; it cannot be generalized to every cause of low testosterone or impaired sperm production.