Ancillary & Wellness · Tablet / Capsule
Levothyroxine, or T4, is the synthetic form of the principal hormone secreted by the thyroid gland. It serves as a circulating precursor for much of the body's active T3. Reference levothyroxine sodium medicines are studied in thyroid-hormone replacement and selected thyroid-cancer suppression settings, where diagnosis determines the meaning of laboratory changes.
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Deiodinase enzymes can convert T4 to T3 or to inactive metabolites in different tissues. Thyroid hormones act through nuclear receptors that regulate transcription, while feedback to the hypothalamus and pituitary affects TSH secretion. Protein binding, tissue conversion and the relatively prolonged persistence of T4 explain why a single serum concentration does not describe every aspect of thyroid-hormone action.
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