Testosterone acetate (TA)

After ester hydrolysis releases testosterone, androgen receptor signaling regulates transcription in reproductive organs, muscle, bone and other tissues. Testosterone can also convert to dihydrotestosterone through 5-alpha reductase and to estradiol through aromatase. Exogenous androgen exposure feeds back on the hypothalamic-pituitary-gonadal axis, potentially suppressing LH, FSH and spermatogenesis. Serum testosterone concentration therefore does not independently describe reproductive function or every tissue effect.