Ancillary & Wellness · Tablet / Capsule
Liothyronine is synthetic triiodothyronine, commonly called T3. T3 is a biologically active thyroid hormone involved in growth, development and metabolic regulation. Reference medicines contain liothyronine sodium. Thyroid-hormone replacement in diagnosed deficiency has a different clinical context from attempts to alter body weight in people with normal thyroid function.
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T3 binds nuclear thyroid-hormone receptors and changes transcription of genes involved in energy expenditure, cardiac function and tissue differentiation. The hypothalamic-pituitary-thyroid axis uses negative feedback to regulate thyroid-stimulating hormone. Serum T3, free thyroid hormones and TSH therefore describe related but different parts of the endocrine system. Excess signaling can affect heart rhythm and bone turnover as well as metabolic measurements.
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